What if aging itself could be rewritten, not just slowed? João Pedro de Magalhães, a molecular biogerontology professor at the University of Birmingham, believes humans could eventually live not just 100 or even 1,000 years, but up to 20,000.
His theory treats aging less like wear and tear on a machine and more like flawed software. Our DNA contains programs that guide us to adulthood, but left running, they may become harmful later in life. By reprogramming cells and repairing DNA, he argues, scientists could turn off those detrimental codes and extend life far beyond its current limits.
Evidence comes from animals that already defy normal lifespans. Bowhead whales live over 200 years with unusually robust DNA repair. Naked mole rats, tiny rodents that outlive their cousins by decades, show extraordinary cancer resistance. Elephants carry multiple copies of cancer-fighting genes like P53. These molecular tricks hint at what human biology might achieve if reengineered.
Drugs such as rapamycin have extended animal lives by 10, 15 percent, but Magalhães insists true breakthroughs will require building cells that do not age at all. In theory, curing aging could push the average human lifespan past 1,000 years, with maximum lifespans stretching toward 20,000, barring accidents or violence.
For now, the science remains aspirational, requiring technologies we don’t yet possess. But the idea reframes aging as a solvable biological puzzle. If cracked, it could mark the greatest leap in human history, not just adding years to life, but thousands.
What if aging itself could be rewritten, not just slowed? João Pedro de Magalhães, a molecular biogerontology professor at the University of Birmingham, believes humans could eventually live not just 100 or even 1,000 years, but up to 20,000.
His theory treats aging less like wear and tear on a machine and more like flawed software. Our DNA contains programs that guide us to adulthood, but left running, they may become harmful later in life. By reprogramming cells and repairing DNA, he argues, scientists could turn off those detrimental codes and extend life far beyond its current limits.
Evidence comes from animals that already defy normal lifespans. Bowhead whales live over 200 years with unusually robust DNA repair. Naked mole rats, tiny rodents that outlive their cousins by decades, show extraordinary cancer resistance. Elephants carry multiple copies of cancer-fighting genes like P53. These molecular tricks hint at what human biology might achieve if reengineered.
Drugs such as rapamycin have extended animal lives by 10, 15 percent, but Magalhães insists true breakthroughs will require building cells that do not age at all. In theory, curing aging could push the average human lifespan past 1,000 years, with maximum lifespans stretching toward 20,000, barring accidents or violence.
For now, the science remains aspirational, requiring technologies we don’t yet possess. But the idea reframes aging as a solvable biological puzzle. If cracked, it could mark the greatest leap in human history, not just adding years to life, but thousands.
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