Flossing could become the future of vaccination. In a groundbreaking study, researchers demonstrated that vaccine-coated dental floss can trigger robust immune responses by targeting a thin, permeable tissue between the teeth and gums called the junctional epithelium. Unlike other parts of the mouth, this layer is rich in immune cells and naturally leaky—perfect for absorbing vaccine molecules.
Using this method, scientists vaccinated mice against influenza by flossing their teeth with strands coated in inactivated virus. The results were remarkable: mice developed strong immunity not only in their gums, but throughout their bodies. Antibodies were detected in saliva, feces, lungs, spleens, and even bone marrow, indicating both mucosal and systemic immune protection. All vaccinated mice survived a lethal flu exposure. Unvaccinated ones did not.
The immune response was also sustained over time, showing promise for long-term protection. Researchers successfully repeated the method with other vaccine types, including mRNA and protein-based formulations, further confirming the versatility of the approach. Notably, eating or drinking after flossing didn’t diminish its effectiveness.
The team also tested delivery with human volunteers using floss picks coated in dye. Around 60% of the dye reached the target tissue—an encouraging sign that floss-based vaccines could be viable for people, too. The technique avoids risks linked to nasal sprays and bypasses needle use entirely.
Beyond effectiveness, this method offers practical advantages: it’s needle-free, requires no refrigeration, and could even be mailed. While it may not work for infants or people with advanced gum disease, it has the potential to revolutionize mass immunization efforts.
Source: s41551-025-01451-3
Using this method, scientists vaccinated mice against influenza by flossing their teeth with strands coated in inactivated virus. The results were remarkable: mice developed strong immunity not only in their gums, but throughout their bodies. Antibodies were detected in saliva, feces, lungs, spleens, and even bone marrow, indicating both mucosal and systemic immune protection. All vaccinated mice survived a lethal flu exposure. Unvaccinated ones did not.
The immune response was also sustained over time, showing promise for long-term protection. Researchers successfully repeated the method with other vaccine types, including mRNA and protein-based formulations, further confirming the versatility of the approach. Notably, eating or drinking after flossing didn’t diminish its effectiveness.
The team also tested delivery with human volunteers using floss picks coated in dye. Around 60% of the dye reached the target tissue—an encouraging sign that floss-based vaccines could be viable for people, too. The technique avoids risks linked to nasal sprays and bypasses needle use entirely.
Beyond effectiveness, this method offers practical advantages: it’s needle-free, requires no refrigeration, and could even be mailed. While it may not work for infants or people with advanced gum disease, it has the potential to revolutionize mass immunization efforts.
Source: s41551-025-01451-3
Flossing could become the future of vaccination. In a groundbreaking study, researchers demonstrated that vaccine-coated dental floss can trigger robust immune responses by targeting a thin, permeable tissue between the teeth and gums called the junctional epithelium. Unlike other parts of the mouth, this layer is rich in immune cells and naturally leaky—perfect for absorbing vaccine molecules.
Using this method, scientists vaccinated mice against influenza by flossing their teeth with strands coated in inactivated virus. The results were remarkable: mice developed strong immunity not only in their gums, but throughout their bodies. Antibodies were detected in saliva, feces, lungs, spleens, and even bone marrow, indicating both mucosal and systemic immune protection. All vaccinated mice survived a lethal flu exposure. Unvaccinated ones did not.
The immune response was also sustained over time, showing promise for long-term protection. Researchers successfully repeated the method with other vaccine types, including mRNA and protein-based formulations, further confirming the versatility of the approach. Notably, eating or drinking after flossing didn’t diminish its effectiveness.
The team also tested delivery with human volunteers using floss picks coated in dye. Around 60% of the dye reached the target tissue—an encouraging sign that floss-based vaccines could be viable for people, too. The technique avoids risks linked to nasal sprays and bypasses needle use entirely.
Beyond effectiveness, this method offers practical advantages: it’s needle-free, requires no refrigeration, and could even be mailed. While it may not work for infants or people with advanced gum disease, it has the potential to revolutionize mass immunization efforts.
Source: s41551-025-01451-3
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