In 1984, a German correspondent living in Paris offered a piece of unconventional advice for anyone attempting to cross the vast and hectic Place de la Concorde. The square was famous for its swirling traffic, constant noise, and the apparent indifference of its drivers, which made even short crossings feel like daring acts. The correspondent explained that the safest approach was to walk forward at a steady and confident pace while refusing to meet the drivers gaze. According to this advice, the moment a pedestrian looked directly at a driver, the driver would assume that the pedestrian had acknowledged the oncoming vehicle and would therefore continue without slowing. By keeping ones eyes fixed ahead and moving with calm determination, the pedestrian signaled uncertainty to the drivers, which in turn encouraged them to yield.

Researchers are closing in on one of the most stubborn molecular drivers of pancreatic cancer. Deep inside tumor cells and the fibrous tissues surrounding them, a fast-acting enzyme called Pin1 rewires signaling pathways that help cancers grow, spread, and evade therapy. A new effort by UC Riverside and City of Hope is using a precision-engineered “molecular crowbar” to pry this enzyme apart and trigger its destruction.⁠ ⁠ The strategy hinges on custom-designed compounds that bind tightly to Pin1, push it into an unstable shape, and mark it for removal by the cell’s own disposal machinery. Instead of simply blocking the enzyme’s activity, these degraders erase the protein entirely, offering a fundamentally different way to dismantle cancer’s internal wiring.⁠ ⁠ To move the approach forward, the teams strengthened the compounds’ stability in blood plasma, then mapped how they affect cancer cells and the surrounding fibroblasts drawn from patient biopsies. That dual targeting is critical, because the tumor microenvironment in pancreatic cancer forms a dense, treatment-resistant barrier that protects malignant cells from chemotherapy and immunotherapy.⁠ ⁠ In mouse models of peritoneal metastases—one of the deadliest complications of pancreatic, gastrointestinal, and abdominal cancers—the degraders sharply reduced tumor burden. The results offer rare proof-of-concept progress against a disease where survival is often measured in months.⁠ ⁠ Backed by a National Cancer Institute cooperative grant, the collaboration is now advancing these degraders toward clinical readiness. Because Pin1 is active across many tumor types, this approach could open a broader therapeutic class built around selective protein dismantling.⁠ ⁠ #tech #biotech #cancerresearch #pancreaticcancer #drugdiscovery #proteindegradation #molecularbiology #innovation #futuremedicine

In Finland, fines aren’t one-size-fits-all, they’re based on your income. That means the wealthier you are, the higher your fine if you break the speed limit 💸🇫🇮 Some high-profile cases have seen drivers pay hundreds of thousands of dollars for speeding! It’s Finland’s way of making sure traffic laws hit everyone equally, regardless of your bank account. 📲 Download the FREE @Travly App to book your next trip 🤍 Link in bio to download! #Travel #explore #traveling

Drivers across the U.S. are now posting a printed sign in their car windows to minimize conversation with police during traffic stops — and the trend has quickly gone viral. The sign, taped inside the glass, lists several asserted rights: the driver will remain silent, won’t consent to a search, and requests an attorney. It also cites laws claiming they don’t need to sign a ticket or hand over a license through the window, instead directing officers to place any documents under the windshield wiper. Legal experts note that while the sign refers to legitimate rights, it doesn’t prevent officers from ordering a driver out of the vehicle when they have legal grounds. They warn that refusing to follow lawful commands can escalate the situation and lead to more serious consequences. - #history #news #funny #memes #photooftheday #explore #didyouknow

Michael Saylor stated this week that he has “no doubt” Bitcoin will overtake gold as the world’s top store-of-value asset. He pointed to accelerating global adoption, ETF inflows, and corporate treasury interest as drivers behind the shift. Saylor added that by 2035 Bitcoin’s market size will make it a foundational asset for both institutions and nations. Download the Movement Market app in my bio and start trading memecoins 🚀

The UK government has launched an official investigation into whether modern LED headlights are excessively bright and creating safety hazards for drivers, following a surge in complaints describing them as “dangerous” and “blinding.” Under its new Road Safety Strategy, the Department for Transport has tasked the Transport Research Laboratory with examining headlight brightness, beam alignment, and height. Early results suggest that SUVs and poorly aligned lights intensify glare, particularly affecting older motorists during nighttime driving. Experts believe tighter regulations on LED brightness could improve road safety, though others warn it may compromise the sleek, modern look of today’s vehicles. The discussion has since gone global, with growing calls for the United States to conduct a similar review. Follow us @FutureTech for more! 🔌

HER2 Human Epidermal Growth Factor Receptor 2 Inhibitors Market Growth: Advancing Cancer Therapeutics The HER2 Human Epidermal Growth Factor Receptor 2 Inhibitors Market is experiencing remarkable growth as targeted therapies reshape oncology treatment strategies worldwide. With the prevalence of HER2-positive breast and gastric cancers steadily increasing, demand for innovative inhibitors is surging. These drugs work by blocking abnormal HER2 protein activity, slowing tumor progression, and enhancing survival outcomes. The growing use of antibody-drug conjugates and next-generation inhibitors has significantly improved efficacy while minimizing treatment resistance. This steady adoption is driving higher revenue generation and accelerating clinical research programs aimed at developing newer, more effective molecules. get full Reports :https://www.marketresearchfuture.com/reports/her2-human-epidermal-growth-factor-receptor-2-inhibitors-market-32322 A key factor fueling market growth is the expanding role of personalized medicine and companion diagnostics. Accurate HER2 testing allows oncologists to identify patients who can benefit the most from these inhibitors, ensuring better outcomes. At the same time, government initiatives promoting cancer awareness and treatment accessibility are strengthening adoption, particularly in emerging regions. Pharmaceutical companies are focusing on robust pipelines and strategic collaborations to accelerate product development and commercialization. For an in-depth understanding of growth opportunities and competitive dynamics, explore the detailed HER2 Human Epidermal Growth Factor Receptor 2 Inhibitors Market growth. FAQs Q1: What drives the growth of the HER2 inhibitors market? A1: Rising cancer prevalence, adoption of precision medicine, and advancements in drug development are major growth drivers. Q2: Which treatment innovations are gaining traction? A2: Antibody-drug conjugates and next-generation tyrosine kinase inhibitors are gaining significant traction for improved patient outcomes.

The battle to preserve our environment is intrinsically linked to the defense of our national sovereignty. How our country positions itself on the global stage, who our natural resources serve, and who dictates the rules of the environmental game are central issues in ensuring a sustainable future for the Brazilian population. In Brazil, agribusiness is one of the main drivers of the worsening environmental and social crisis. Characterized by land concentration, monoculture of commodities for export, deforestation for agricultural expansion, and the intensive use of pesticides and water, this model is proving increasingly unsustainable. In 2023 alone, 3.7 million hectares of forest were cleared worldwide, largely to make way for livestock and agribusiness crops. 📲 Read the full article by Miguel Enrique Stedile on our website.

In the heart of Seoul, South Korea, is reshaping how cities think about pedestrian safety. Instead of scolding people for staring at their phones while crossing the street, city officials are building infrastructure that accommodates it. At nearly 1,200 intersections across Seoul, including 138 in Gangnam alone, glowing LED traffic lights have been embedded directly into the pavement—right at the edge of the sidewalk. Their purpose is to catch the attention of people looking down at their screens.⁠ ⁠ These in-ground lights glow red or green, synchronized with traditional signal poles. When the light is red, a band of illuminated warning pulses at their feet. When green, the path clears. The initiative began as a pilot program in 2019, prompted by a spike in accidents involving so-called “smombies”—a mashup of “smartphone” and “zombie,” describing pedestrians too distracted to look up. South Korea’s staggering smartphone penetration rate—over 94% as of 2017—has only compounded the issue.⁠ ⁠ But the glowing pavement is just one layer of Seoul’s multi-tiered “smart crossing” initiative. In more advanced intersections, sensors detect approaching pedestrians and trigger a range of safety measures: visual ground projections, alerts sent to nearby smartphones, and flashing signals aimed at oncoming drivers. Some crossings even use thermal and radar cameras to monitor foot traffic and adjust signals dynamically.⁠ ⁠ Unexpectedly, the benefits go beyond smartphone users. City officials have noted improvements in school zones, where the lights help young children stay farther from the curb. With over half of all traffic deaths in Seoul involving pedestrians as of 2020, these targeted interventions are already saving lives.⁠ ⁠ By embracing behavioral realities rather than resisting them, Seoul offers a compelling model for cities everywhere. When the future refuses to look up, the answer might just lie at our feet.

Funds like VOO, VTI, or VT are great core drivers of long-term growth. The ETFs in this post are considered Satellite ETFs. Think of them as optional "add-ons" circling your core ETF. They can boost returns if the theme is hot (AI, energy, defense) but they can also drag you down if you lean on them too much. Still better odds than stock picking though. The key is knowing the difference between core vs satellite positions. Most beginners skip straight to the flashy stuff and miss building the foundation. I also just launched my brand new 16-step “Before You Start Investing” Checklist. This covers everything you need to have in place before you put a single dollar in the market. Comment “Checklist” below and I’ll send it over for free. 🔥